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for People with Rare Diseases

Centrum für Chronische Immundefizienz (CCI) am Universitätsklinikum Freiburg

Description of facility

Director / Spokesperson
Prof. Dr. Stephan Ehl
Information
Care facility for adults and children
Description

Das Centrum für Chronische Immundefizienz (CCI) widmet sich der Diagnose und Behandlung von Immundefekten sowie der Erforschung des Immunsystems. Das Besondere am CCI ist die Zusammenführung von Experten aus den Bereichen Immunologie, Infektiologie, Rheumatologie, Hämatologie, sowie Zell- und Gentherapie in einem Zentrum. Das CCI hat sich zur wichtigsten Anlaufstelle in Deutschland für Patienten mit Immundefekterkrankungen entwickelt. Es werden Patienten mit angeborenen oder erworbenen Immundefekten, häufigen Infekten, ungewöhnlichen Infektionen, unklaren Entzündungen oder Autoimmunerkrankungen diagnostiziert und behandelt. In enger Zusammenarbeit mit den Abteilungen für (Pädiatrische) Hämatologie/Onkologie verfügt das CCI über große Erfahrung in der Stammzelltransplantation bei Immundefekten sowie in der Durchführung früher klinischer Studien zur Untersuchung innovativer Therapien.

Das CCI verfügt über fünf Funktionsmodule. Das Modul „Patientenversorgung“ ist in den Ambulanzen für Immunologie und Pädiatrische Immunologie organisiert. Die Betreuung stationärer Patienten erfolgt in der Kinderklinik sowie in der Medizinischen Klinik unter Einbeziehung der Stationen für Knochenmarkstransplantation. Das „Diagnostikmodul“ besteht aus einer „Advanced Diagnostic Unit“, das als eines der wenigen Labore in Deutschland als wichtiges Referenzlabor für Kliniken aus dem In- und Ausland fungiert, sowie einer Genetics/Genomics-Unit. Ferner betreibt das CCI ein Modul „Klinische Forschungseinheit“ zur Unterstützung von klinischen Studien, sowie ein Modul „Ausbildung/Karriereförderung.“ Im Modul „Forschung“ arbeiten 15 Arbeitsgruppen an verschiedenen Themen der Immundefizienzforschung.

Care provisions

This facility offers the following
  • Participation in registries
  • Social / legal advice
  • Genetic counselling
  • Clinical studies / research

    http://www.uniklinik-freiburg.de/cci/studien.html

  • Diagnostic
  • Therapy
  • Contact person for patients with an unclear diagnosis

    Patienten mit pathologischer Infektanfälligkeit; Patienten mit Entzündungs- oder Autoimmunerkrankungen in Verbindung mit Infektanfälligkeit; Patienten mit unklaren Immundefekten.

  • Contact with support groups

    Deutsche Selbsthilfe angeborene Immundefekte (dsai), Wir sind 22q11 e.V., ALPS-Selbsthilfe

Contact

Prof. Dr. Klaus Warnatz
0761 27045240
klaus.warnatz@uniklinik-freiburg.de
Website https://www.uniklinik-freiburg.de/fzse/fachzentren-und-krankheitsbilder/centrum-fuer-chronische-immundefizienz.html

Secondary Contact

Prof. Dr. Stephan Ehl
0761 27043000
stephan.ehl@uniklinik-freiburg.de

Address

Breisacher Straße 115
79106 Freiburg

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Languages

Germany.png Deutsch
United_Kingdom.png Englisch
France.png Französisch

European Reference Network 1

Mentioned by the following facilities 1

Preview of the assigned diseases 1

Severe combined immunodeficiency Immunodeficiency due to interleukin-1 receptor-associated kinase-4 deficiency Cernunnos-XLF deficiency Immunodeficiency by defective expression of MHC class II Severe combined immunodeficiency due to adenosine deaminase deficiency Immunodeficiency by defective expression of MHC class I Absent thumb-short stature-immunodeficiency syndrome Immunodeficiency due to CD25 deficiency Immunodeficiency due to selective anti-polysaccharide antibody deficiency Developmental delay-immunodeficiency-leukoencephalopathy-hypohomocysteinemia syndrome Genetic immune deficiency with skin involvement Facial dysmorphism-immunodeficiency-livedo-short stature syndrome CEBPE-associated autoinflammation-immunodeficiency-neutrophil dysfunction syndrome Good syndrome Immunodeficiency due to MASP-2 deficiency Autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity Immunodeficiency due to a complement regulatory deficiency Immunodeficiency due to a complement cascade component deficiency Immunodeficiency due to a classical component pathway complement deficiency T-B+ severe combined immunodeficiency due to JAK3 deficiency Autoinflammatory syndrome with immune deficiency Severe combined immunodeficiency due to DCLRE1C deficiency T-B+ severe combined immunodeficiency due to gamma chain deficiency Combined immunodeficiency-enteropathy spectrum Immune deficiency with skin involvement Combined immunodeficiency due to RELA haploinsufficiency Non-severe combined immunodeficiency Common variable immunodeficiency Pancytopenia due to IKZF1 mutations Acquired immunodeficiency Combined immunodeficiency due to OX40 deficiency Combined immunodeficiency due to DOCK8 deficiency Primary immunodeficiency with predisposition to severe viral infection Laron syndrome with immunodeficiency Primary immunodeficiency with post-measles-mumps-rubella vaccine viral infection Primary immunodeficiency due to a defect in adaptive immunity PLCG2-associated antibody deficiency and immune dysregulation Combined immunodeficiency due to STK4 deficiency Combined immunodeficiency due to CD70 deficiency Severe combined immunodeficiency due to LCK deficiency Combined immunodeficiency due to CARMIL2 deficiency Immunodeficiency predominantly affecting antibody production Combined immunodeficiency due to ITK deficiency Combined immunodeficiency due to LRBA deficiency Primary immunodeficiency due to a defect in innate immunity Immunodeficiency due to a complement cascade protein anomaly Primary immunodeficiency Combined immunodeficiency due to CARD11 deficiency FADD-related immunodeficiency Combined immunodeficiency due to FCHO1 deficiency Combined immunodeficiency due to CD3gamma deficiency Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome Griscelli syndrome Primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency DNA repair defect other than combined T-cell and B-cell immunodeficiencies Combined immunodeficiency due to CRAC channel dysfunction Omenn syndrome Severe combined immunodeficiency due to FOXN1 deficiency Nijmegen breakage syndrome Immunodeficiency syndrome with autoimmunity Combined immunodeficiency due to MALT1 deficiency Combined immunodeficiency due to GINS1 deficiency Combined immunodeficiency due to ZAP70 deficiency Autosomal recessive combined immunodeficiency due to complete IL6ST deficiency Immune dysregulation disease with immunodeficiency Neutrophil immunodeficiency syndrome Lung fibrosis-immunodeficiency-46,XX gonadal dysgenesis syndrome Severe combined immunodeficiency due to CORO1A deficiency PGM3-CDG Autosomal recessive combined immunodeficiency due to partial IL6ST deficiency Autosomal recessive mendelian susceptibility to mycobacterial diseases due to complete RORgamma receptor deficiency Combined immunodeficiency due to CD27 deficiency Immune deficiency due to impaired neutrophil phagocytosis and migration Immunodeficiency due to ficolin3 deficiency Autosomal dominant combined immunodeficiency due to partial IL6ST deficiency Familial hyperinflammatory lymphoproliferative immunodeficiency Immunodeficiency due to a late component of complement deficiency X-linked combined immunodeficiency due to SASH3 deficiency T-B+ severe combined immunodeficiency due to IL-7Ralpha deficiency Congenital sideroblastic anemia-B-cell immunodeficiency-periodic fever-developmental delay syndrome Severe combined immunodeficiency due to complete RAG1/2 deficiency B-cell immunodeficiency-limb anomaly-urogenital malformation syndrome T-B+ severe combined immunodeficiency due to CD45 deficiency T-B+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta Autosomal recessive combined immunodeficiency due to IL6R deficiency Severe combined immunodeficiency due to CTPS1 deficiency Severe combined immunodeficiency due to IKK2 deficiency Anhidrotic ectodermal dysplasia-immunodeficiency-osteopetrosis-lymphedema syndrome Immunodeficiency with factor I anomaly Periodic fever-immunodeficiency-thrombocytopenia syndrome Immunodeficiency with isotype or light chain deficiencies with normal number of B-cells Immunodeficiency with factor H anomaly T-B+ severe combined immunodeficiency Immunodeficiency with severe reduction in serum IgG and IgA with normal/elevated IgM and normal number of B-cells T-B- severe combined immunodeficiency Combined immunodeficiency due to ORAI1 deficiency Combined immunodeficiency due to partial RAG1 deficiency Combined immunodeficiency due to STIM1 deficiency Immunodeficiency-associated lymphoproliferative disease Severe combined immunodeficiency due to DNA-PKcs deficiency NIK deficiency Hoyeraal-Hreidarsson syndrome Adult-onset immunodeficiency with anti-interferon-gamma autoantibodies Hypohidrotic ectodermal dysplasia with immunodeficiency Combined immunodeficiency with granulomatosis Combined immunodeficiency due to DOCK2 deficiency

Provided care options 2

# Contact person
1
Pädiatrische Immunologie
Prof. Dr. Stephan Ehl

0761 27043000
Email
Website
Sprechzeiten nach Vereinbarung.
This consultation offers genetic counselling.

2
Immunologie für Erwachsene
Prof. Dr. Klaus Warnatz

0761 27077640
Email
Website
Sprechzeiten nach Vereinbarung.
This consultation offers genetic counselling.

7.83783359259033248.0074256985175Centrum für Chronische Immundefizienz (CCI) am Universitätsklinikum Freiburg
Last updated: 23.04.2025